I have been thinking about what it means to buy issues from month to month. Some of the fun and wonder of comic books have actually been diminished, IMO, by being collected and only read in collected form. Of course the convenience and resale value make it more than worth it to purchase comic trades but having a story unfold over time has a kind of charm and surprise that you just don’t get with collected editions. I believe this is especially true with Silver and Bronze Age issues. I’ll argue until the day I that I die that Crisis on Infinite Earths is better when read over 12 months rather than just over a weekend.
However, I do agree that it really doesn’t matter for comics published nowadays as most of today’s comic books are really written to be collected. My thoughts are just kinda nostalgic for a previous four-color era I guess.
Here are some titles that came out when I was a kid and as a teenager that I regret not picking up for one reason or another. These series may have been great or merely mediocre but at the time they were published I think I would have greatly enjoyed them. That's not to say I didn't pick up a few issues of some of theses guys here and there but rather that I never picked these comics up on a regular basis.
George Pérez's Wonder Woman
New Teen Titians
Dark Horse Presents
DC's Star Trek
Amethyst (1st series only)
Arak Son of Thunder